Effect of hormone replacement therapy on markers of bone metabolism in RA.

own.2 There has been another report of this condition with another rheumatic disease, rheumatoid arthritis.3 As such cases tend to be reported in ophthalmological journals it is possible that this association may be more common than is realised. We would like to draw your attention to a case of 'Brown's syndrome' that we have previously reported in association with another connective tissue disease, scleroderma.4 The patient was a 27 year old Eurasian woman who had had scleroderma with diffuse skin involvement for 10 years. There was marked systemic disease with joint contractures, scleroderma oesophagus, and restrictive lung disease. She had previously been treated intermittently with oral prednisolone and D-penicillamine without any marked benefit and was currently taking cimetidine and receiving periodic oesophageal dilatation for her gastro-oesophageal reflux and conse-